ew.com:

I can’t wait until new Gossip Girl!!! Can you PLEASE share some Chuck and Blair spoilers? Thank you. — Karen
For old time’s sake, there’s a Chuck and Blair scene in a limo in the Oct. 8 premiere. But I won’t say what goes down.

I’m dying for some Serena/Blair, Chuck/Blair or Serena/Nate scoop! — Kellie
One of these pairs is on the worst terms they’ve ever been by the end of the premiere episode. And by the second episode, another pair will be connected in a completely unexpected (and, some might argue, twisted) way.